In recent years, migraine has emerged as an established risk factor for myocardial infarction (MI) and stroke. Migraine is a common headache disorder with an age-standardized prevalence of 14%. Integrated Database for Labor Market Research MI, None of these studies has any relation to the present study.Ĭhronic obstructive pulmonary disease CPR, The Department of Clinical Epidemiology, Aarhus University, receives funding for other studies in the form of institutional research grants to (and administered by) Aarhus University. MS is supported by the Novo Nordisk Foundation (grant NNF19OC0054908). The funding source had no role in the study design data collection, analysis, or interpretation writing the report or decision to submit the manuscript for publication.Ĭompeting interests: CHF owns stock in Novo Nordisk. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: The individual-level data used for this study are not publicly available, but can be obtained by application to Statistics Denmark ( ).įunding: CHF is supported by Aarhus University. Received: DecemAccepted: ApPublished: June 13, 2023Ĭopyright: © 2023 Hvitfeldt Fuglsang et al. The main limitation of this study was the risk of misclassification of migraine, which could lead to underestimation of the impact of migraine on each outcome.Ĭitation: Hvitfeldt Fuglsang C, Pedersen L, Schmidt M, Vandenbroucke JP, Bøtker HE, Sørensen HT (2023) Migraine and risk of premature myocardial infarction and stroke among men and women: A Danish population-based cohort study. The RD of premature hemorrhagic stroke for migraine versus no migraine was 0.1% (95% CI p = 0.011) for women and −0.1% (95% CI p = 0.176) for men. The RD of premature ischemic stroke for migraine versus no migraine was 0.3% (95% CI p < 0.001) for women and 0.5% (95% CI p < 0.001) for men. The RD of premature MI for those with migraine versus no migraine was 0.3% (95% CI p < 0.001) for women and 0.3% (95% CI p = 0.061) for men. HRs were adjusted for age, index year, and comorbidities. The main outcome measures to assess impact of migraine were absolute risk differences (RDs) and hazard ratios (HRs) with 95% confidence intervals (CIs) of premature MI, ischemic, and hemorrhagic stroke, comparing individuals with migraine to migraine-free individuals of the same sex. Median age was 41.5 years for women and 40.3 years for men. ![]() ![]() All individuals were required to be between 18 and 60 years old. These individuals were matched on sex, index year, and birth year 1:5 with a random sample of the general population who did not use migraine-specific medication. Redeemed prescriptions for migraine-specific medication were used to identify women with migraine ( n = 179,680) and men with migraine ( n = 40,757). Using Danish medical registries, we conducted a nationwide population-based cohort study (1996 to 2018).
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